Pharmaceutical R&D on neuropathic pain

[Dave]

By the way, i found that very interesating page
http://www.nature.com/nrd/journal/v11/n ... nrd3624_T1.

Thanks. A good find at that link is Ralfinamide, a drug in phase 2.  The maker is Newron Pharmaceuticals, an Italian company. They claim that Ralfinamide is an inhibitor of sodium channels, calcium channels, and NMDA receptors.

[jogom]

and finally
http://www.biocetera.com/inthenews.php?id=148537
I hope it can be on the market soon.

[jogom]

Does anybody hear aboute XEN402?

[Dave]

Does anybody hear aboute XEN402?

This drug is interesting because Xenon looks for cures by studying the "opposite phenotype."   For example, they have been looking for chronic pain cures by studying the genes of people who congenitally cannot feel pain.  It is one of the few  companies really looking at pain from a DNA level.

This drug XEN402 is targeted to a very specific sodium channel in the nerve associated with pain.  Let's HOPE it is successful... 

[jogom]

I gess you mean the SCN9A of a pakistani family. I see you know a lot of companies that are involved on research.

[Dave]

Nektar Therapeutics (CA) is another company doing some interesting work. Their main focus seems to be using their polymer drug delivery technology to reduce the adverse effects of opioids:

scroll down to the "pain" section:
http://www.nektar.com/product_pipeline/ ... l#NKTR-171

http://www.marketwatch.com/story/nektar ... 2012-06-07

[Dave]

See also news on Sativex (GW Pharma). This product is a marijuana extract in a spray form. The first application is cancer pain, but it will also be trialed for neuropathic pain.

http://americannewsreport.com/marijuana ... 14518.html

http://www.gwpharm.com/sativex.aspx

http://www.gwpharm.com/Third%20phase%20 ... ences.aspx

[Dave]

This is a very long way from being commercially available, but if there is any to this gene therapy for neuropathic pain, it would be a phenomenal breakthrough. If our great grandchildren can simply go to the doctor and be cured of this....

http://www.diamyd.com/docs/ntddsPlatfor ... on=science

[Dave]

Btw, here is another company in Virginia and another in Spain.

http://www.xdynia.com
http://www.esteve.es/EsteveFront/Cargar ... idi&lng=en

[helenlegs 11]

deadly-black-mamba-venom-could-kill-pain

http://news.sky.com/story/992914/deadly ... -kill-pain